Mannitol cannot reduce the mortality on acute severe traumatic brain injury (TBI) patients: a meta–analyses and systematic review

Table 6 CPP of included studies

		Measurement of surrogate index			Measurement of surrogate index
		Number of episodes per day			Total duration of episodes, min/day
Vialet et al. [49]	Intervention: 20 % M 2 mL/Kg	3.1 ± 3.6^**			62 ± 107^**
Vialet et al. [49]	Control: 7.5 % HSS 2 mL/Kg	4.0 ± 4.6^**			58 ± 83^**
		T0	T30	T60	T90	T120
Harutjunyan et al. [50]	Intervention: 15 % M 1.4 mL/Kg	61 [47–71]	72 [60–93]^*	73 [58–88]^,*
Harutjunyan et al. [50]	Control: 7.2 % NaCl/HES 1.8 mL/Kg	60 [39–78]	75 [62–86]^,*	69 [56–89]^*
Cottenceau et al. [52]	Intervention: 20 % M 4 mL/Kg	72.1 ± 12.8	76.9 ± 17.4⁸			74.7 ± 13.3^*
Cottenceau et al. [52]	Control: 7.5 % HSS 2 mL/Kg	72.8 ± 15.1	79.3 ± 11.6^*			74.3 ± 13.1^*
		Δ%	Δ%	Δ%	Δ%	Δ%
Francony et al. [51]	Intervention: 20 % M 231 mL	75 ± 15	+21 ± 23^*	+22 ± 21^*	+14 ± 15^*	+17 ± 14^*
Francony et al. [51]	Control: 7.45 % HSS 100 mL	81 ± 12	+21 ± 23^*	+9 ± 10^*	+8 ± 11^*	+7 ± 6^*

ISSN: 2321-3876