From: Tissue engineering of skin and regenerative medicine for wound care
Cutaneous structures and phenotypes | Regulatory pathways and factors |
---|---|
Epidermal barrier | |
Dermal-epidermal junction | PKB/Akt-ERK1/2 [125] |
Hair follicle genesis and cycling | |
Sebaceous glands | Wnt; Blimp1; IHH; c-myc [131] TGFβ-1 [132] |
Sweat glands | Wnt/β-catenin [133] EDA/EDAR/NF-κB [134] DKK4, SHH [135] |
Pigmentation | c-kit/SCF; [136] ET-3/EDNRB2 [137] Sox-10/Mitf; Eph/EphR; [138] |
Sensory and motor innervation | c-jun [139] Sox-2,-10 [55] Oct-6; Krox-20; Pax 3 [140] |
Cardiovascular system | Sox-7, -17, -18 [141] Mef2c/β-catenin [142] VEGF; HOXA9, VEZF1 [143] |
Subcutaneous fat | PPARγ [144] Pref-1; Fabp4 [145] Myf5; Ebf2; Prdm16; Pgc-1α [146] |