Table 1 Search terms and search strategy

PubMed

1. (Mannitol OR Mannit OR Mannite OR Osmosal OR Osmosteril OR Resectisol OR Aridol OR Bronchitol)

#1 AND #2 AND #3

2. (“intracranial pressure” OR “intracranial hypotension” OR “intracranial hypertension” OR brain)

3.((randomized controlled trial[pt] OR controlled clinical trial[pt]OR (“Clinical Trials as Topic” [MeSH Major Topic])) NOT ((“Animals” [MeSH]) NOT (“Humans” [MeSH] AND “Animals” [MeSH]))

ISI

1. Topic = (mannitol or Mannit or Mannite or Osmosal or Osmosteril or Resectisol or Aridol or Bronchitol)

1 and 2 and 3

2. Topic = (intracranial pressure OR intracranial hypotension OR intracranial hypertension OR brain*)

3. TS = (clinical OR control* OR placebo OR random OR randomised OR randomized OR randomly OR random order OR random sequence OR random allocation OR randomly allocated OR at random)

Cochrane

1.(mannitol OR Manit OR Mannite or Osmosal or Osmosteril or Resectisol or Aridol or Bronchitol)

1AND (2 OR 3 OR 4)

2. “intracranial pressure”

3. “intracranial hypotension”

4. “intracranial hypertension”

CBM

1. “mannitol” [Full field] 2. “mannitol” [MeSH])” 3. brain injury” [Full field] 4. “Head injury” [MeSH] 5. “Parietal damage” [Full field] 6. “Frontal damage” [Full field] 7. “Temporal damage” [Full field] 8. “Head injury” [Full field] 9. “Occipital damage” [Full field] 10. “Brain Injury” [MeSH] 11. “intracranial hypotension” [Full field] 12. “intracranial hypotension” [MeSH] 13. “Animal experiments” [Full field] 14. “Animal experiments” [MeSH]

(1 OR 2) AND (3 OR 4 OR 5 OR 6 OR 7 OR 8 OR 9 OR 10) AND (11 OR 12) NOT (13 OR 14)

CNKI

1. KY = mannitol 2. KY = brain injury 3. KY = intracranial hypotension 4. KY = animals

1 AND 2 AND 3 NOT 4