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Vialet et al. [49]
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Severe head injury (GCS <8); follow up to 3 months
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The mannitol group receives 20 % mannitol solution. The hypertonic saline group received 7.5 % hypertonic saline. The infused volume was the same for the both solutions: 2 mL/kg body weight in 20 min
|
Death and neurological disability reported
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HS caused a greater decrease in ICP than mannitol
|
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Harutjunyan et al. [50]
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Severe neuronal damage (GCS <8).
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Seventeen patients received 7.2 % NaCl/HES 200/0.5 and 15 received mannitol
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Death reported
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HES caused a greater decrease in ICP than mannitol (57 vs. 48 %; p <0.01)
|
|
Francony et al. [51]
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Severe brain injury (trauma, stroke); they were aged >18 years and had sustained elevated ICP of >20 mmHg for >10 min. Follow up to 3 months
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The mannitol group received 231 mL of 20 % mannitol. The hypertonic saline group received 100 mL of 7.45 % hypertonic saline. Both to be administrated via the central venous catheter in 20 min
|
ICP, CPP, MAP reported
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ICP decreasing did not differ between the two groups. Mannitol if effective than HS in CPP
|
|
Cottenceau et al. [52]
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Severe head injury (GCS <8); follow up to 6 months
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The mannitol group received 4 mL/Kg of 20 % mannitol. The hypertonic saline group received 2 mL/Kg of 7.5 % hypertonic saline. Both be administrated in 20 min
|
Neurological outcome reported
|
Neurological outcome and ICP decreasing did not differ between the groups
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