Mannitol cannot reduce the mortality on acute severe traumatic brain injury (TBI) patients: a meta–analyses and systematic review

Table 5 ICP of included studies

		Measurement of surrogate index			Measurement of surrogate index
		Number of episodes per day			Total duration of episodes, min/day
Vialet et al. [49]	Intervention: 20 % M 2 mL/Kg	13.3 ± 14.2^**				95 ± 92^**
Vialet et al. [49]	Control: 7.5 % HSS 2 mL/Kg	6.8 ± 5.5^**				62 ± 81^**
		T0	T30	T60	T90	T120
Harutjunyan et al. [50]	Intervention: 15 % M 1.4 mL/Kg	23 [19–30]	12 [6–19]^*	14 [7–20]^,*
Harutjunyan et al. [50]	Control: 7.2 % NaCl/HES 1.8 mL/Kg	22 [19–31]	10 [6–14]^*	11 [5–18]
Cottenceau et al. [52]	Intervention: 20 % M 4 mL/Kg	16.3 ± 9.3	10.5 ± 6.8^*			13.6 ± 7.5^*
Cottenceau et al. [52]	Control: 7.5 % HSS 2 mL/Kg	17.9 ± 9.9	13.9 ± 7.8^*			13.9 ± 7.8^*
		Δ%	Δ%	Δ%	Δ%	Δ%
Francony et al. [51]	Intervention: 20 % M 231 mL	31 ± 6	−41 ± 23^*	−45 ± 19^*	−35 ± 12^*	−32 ± 12^*
Francony et al. [51]	Control: 7.45 % HSS 100 mL	27 ± 3	−37 ± 18^*	−35 ± 14^*	−31 ± 15^*	−23 ± 10^*

ISSN: 2321-3876