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Table 5 ICP of included studies

From: Mannitol cannot reduce the mortality on acute severe traumatic brain injury (TBI) patients: a meta–analyses and systematic review

   Measurement of surrogate index Measurement of surrogate index
Number of episodes per day Total duration of episodes, min/day
Vialet et al. [49] Intervention: 20 % M 2 mL/Kg 13.3 ± 14.2**     95 ± 92**
Control: 7.5 % HSS 2 mL/Kg 6.8 ± 5.5**     62 ± 81**
   T0 T30 T60 T90 T120
Harutjunyan et al. [50] Intervention: 15 % M 1.4 mL/Kg 23 [19–30] 12 [6–19]* 14 [7–20]*,**   
Control: 7.2 % NaCl/HES 1.8 mL/Kg 22 [19–31] 10 [6–14]* 11 [5–18]   
Cottenceau et al. [52] Intervention: 20 % M 4 mL/Kg 16.3 ± 9.3 10.5 ± 6.8*    13.6 ± 7.5*
Control: 7.5 % HSS 2 mL/Kg 17.9 ± 9.9 13.9 ± 7.8*    13.9 ± 7.8*
   Δ% Δ% Δ% Δ% Δ%
Francony et al. [51] Intervention: 20 % M 231 mL 31 ± 6 −41 ± 23* −45 ± 19* −35 ± 12* −32 ± 12*
Control: 7.45 % HSS 100 mL 27 ± 3 −37 ± 18* −35 ± 14* −31 ± 15* −23 ± 10*
  1. *P <0.05 vs. T0; **P < 0.05 vs. mannitol