Mannitol cannot reduce the mortality on acute severe traumatic brain injury (TBI) patients: a meta–analyses and systematic review

Table 8 Plasma osmolality and serum sodium of included studies

	Measurement of surrogate index		Intervention	Control
Vialet et al. [49]	Serum sodium (Δ%)		+1.3 ± 10.1^*	+4.7 ± 8.2^*
Francony et al. [51]	Serum sodium (Δ%)		−1.7 ± 3.2^**	+2.1 ± 1.4^**
Francony et al. [51]	Urine output (mL/h)		306 ± 174^**	114 ± 72^**
Harutjunyan et al. [50]	Serum sodium	T0		143 (136–148)
	Serum sodium	T30		148 (144–153)^*
	Plasma	T0	286 (270–315)^*	284 (273–300)^*
	Osmolality	T30	295 (278–327)^*	300 (284–319)^*
Cottenceau et al. [52]	Serum sodium	T0	141.3 ± 5.1	144.2 ± 5.1
Cottenceau et al. [52]	Serum sodium	T30	139.1 ± 4.1^,*	148.3 ± 5.2^,*

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