Table 1 A selection of commercially available skin substitutes
Product | Manufacturer | Basic composition |
|---|---|---|
Bilayered (dermo-epidermal) substitutes | ||
Apligraf ® | Organogenesis Inc., MA, USA | Bovine collagen I gel with allogeneic human keratinocytes and fibroblasts |
OrCel â„¢ | Forticell Bioscience Inc., NY, USA | Bovine collagen sponge with allogeneic fibroblasts and keratinocytes |
Epidermal substitutes | ||
Epicel ® | Genzyme Corporation, Cambridge MA, USA | Cultured substitute: autologous keratinocytes with murine fibroblasts |
Laserskin ® | Fidia Advanced Biopolymers, Abano Terme, Italy | Cultured substitute: benzyl esterified hyaluronic acid derivative with autologous keratinocytes |
Dermal substitutes | ||
Matriderm ® | MedSkin Solutions Dr. Suwelack AG, Billerbeck, Germany | Acellular bovine dermis |
Alloderm ® | LifeCell Corporation, Bridgewater, NJ, USA | Acellular human dermis |
Integra ® | Integra Life Sciences Corp., NJ, USA | Bovine collagen and glycosaminoglycan with silicone top layer |
Oasis ® | Smith & Nephew Inc. Fort Worth, TX, USA | Porcine small intestine submucosa |
Glyaderm ® | Euro Skin Bank (ESB), Beverwijk, The Netherlands. | Acellular human dermis |
Permacol â„¢ | Covedien, Mansfiels, MA, USA | Acellular porcine dermis |
Graftjacket ® | Wright Medical technology Inc., Memphis, TN, USA | Acellular human dermis |
Dermagraft ® | Organogenesis Inc., MA, USA | Allogeneic human fibroblasts and polyglactin mesh scaffold |
EZ Derm ® | Mölnlycke Health Care AB, Gothenburg, Sweden | Porcine collagen dermis |