Fig. 1

Representative histological slides of skin wound tissue of various groups on day 21 after burn injury. a Sham group with no histological changes; b burn injury group slide is characterized by incomplete formation of epithelial layer, inflammatory tissue damage, and edema; c cream base-treated group showing significant inflammatory damage and tissue edema; and d 0.01 % isoquercetin-based cream-treated group showing significant healing of burned tissue. The cellular structure of dermal layers has been restored. The signs of necrosis have been limited to most extent, and the tissue is devoid of any peri-vascular infiltration into tissue spaces. e 0.02 % isoquercetin-based cream-treated group showing more re-structuring and re-organizing of burned tissue. The process of tissue necrosis appears halted and tissue spaces less widened. f 0.04 % isoquercetin-based cream-treated group showing partial reformation of the epithelial layer with signs of tissue re-structuring and healing. g 0.06 % isoquercetin-based cream-treated group showing almost complete formation and healing of the epithelial layer. Moreover, there is less edematous swelling of tissue. h Standard (silver sulfadiazine) cream-treated group characterized by significant tissue repair and re-structuring with little edematous fluid