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Fig. 5 | Burns & Trauma

Fig. 5

From: Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1

Fig. 5

Localization of basement membrane components and vimentin in keloid scar tissue and normal skin. (af) Immunohistochemical localization of laminin-332 (LAM; red) and vimentin (VIM; green) in keloid scar (ac) and normal skin (df). gl Localization of integrin α6 (ITGA6; red) and vimentin (VIM; green) in keloid scar (gi) and normal skin (jl). A single section is shown in each row. Panels in the right column (c, f, i, l) show merged images; inset images are twofold magnifications of boxed areas. Arrows indicate vimentin-positive cells in regions with apparent gaps in basement membrane staining for laminin-332 or integrin α6. Arrowheads (gl) indicate blood vessels displaying colocalization of integrin α 6 and vimentin in keloid scar (gi) and normal skin (jl). All panels are shown at the same magnification; scale bar in panel a, 100 μm

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