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Fig. 6 | Burns & Trauma

Fig. 6

From: Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1

Fig. 6

Characterization of vimentin-positive cells in keloid epidermis. Immunohistochemistry was performed to localize vimentin and markers for basement membrane, basal keratinocytes, Langerhans cells, and melanocytes in keloid scar tissue. (ad) Localization of laminin-332 (LAM; green, a), keratin 15 (KRT15; red, b), and vimentin (VIM; blue, c), and merged image (d). Arrows indicate cells at gaps in basement membrane that are negative for keratin 15 and positive for vimentin. (eh) Localization in keloid epidermis of integrin α6 (ITGA6; red, e), langerin (LANG; green, f), and vimentin (VIM; blue, g), and merged image showing colocalization (h). Arrows indicate examples of cells positive for both langerin and vimentin; arrowhead indicates vimentin-positive, langerin-negative epidermal cell. (il) Localization in keloid scar of integrin α6 (ITGA6; red, i), tyrosinase-related protein 1 (TYRP1; green, j), vimentin (blue, k), and merged image showing colocalization (l). A single section is shown in each row. Scale bar in a is same for all sections, 50 μm

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