The diagnostic and prognostic value of systems biology research in major traumatic and thermal injury: a review

Burns & Trauma

Table 2 Examples of trauma-induced inflammatory responses that are associated with and/or predictive of adverse patient outcomes

	Increased risk of nosocomial infection	Development of sepsis	Development of MODS/MOF	Mortality
IL-6	Elevated levels at admission post blunt trauma [60]	Elevated levels following thermal injury [55, 56]	Elevated levels post severe trauma [43, 53, 94]	Elevated in non-survivors following thermal injury [10, 11, 45, 47] and TBI [42]
IL-8		Elevated levels following thermal injury [55, 56]		Elevated in non-survivors following thermal injury [10, 45, 47] and TBI [42]
IL-10			Elevated levels post severe trauma [43]	Elevated levels associated with increased risk of death post thermal injury [95] and TBI [42, 50]
IL1-RA	Elevated levels at admission post blunt trauma [60]		Elevated levels post severe traum [43, 94]	Elevated in non-survivors following thermal injury [11, 47]
MCP-1	Elevated levels at admission post blunt trauma [60]			Elevated in non-survivors following thermal injury [10, 11, 47]

Abbreviations: IL interleukin, IL1-RA interleukin 1 receptor antagonist, MCP-1 monocyte chemoattractant protein, MODS multiple organ dysfunction syndrome, MOF multiple organ failure, TBI traumatic brain injury

ISSN: 2321-3876