Table 1 Commonly prescribed NSAIDs and their pharmacology
Enzyme inhibited | Name | Bio-availability (%) | Half-life (h) | Dose (mg) | Dosing interval (h) | Max daily dose (mg) | |
|---|---|---|---|---|---|---|---|
Chemical | Trade | ||||||
COX-1 and COX-2 | Aspirin | 50–75 | 0.33 | Enteric coated: 325 500 650 | 4 | 4000 | |
Ibuprofen | Advil Motrin IB | 80 | 2 | 200 | 4–6 | 1200 | |
Diclofenac potassium | Cambia Cataplase Zipsor | 50–55 | 1–2 | 25 50 | 6–12 | 200 | |
Indomethacin | Tivorbex | ~ 100 | 7.6 | 20 40 | 8–12 | 200 | |
Naproxen | Aleve Naprosyn | 95 | 12–17 | 375 500 | 6–8 | 1250 | |
Piroxicam | Feldene | N/A | 50 | 10 20 | 24 | 20 | |
Etodolac | Lodine | 80 | Tablet: 6.4 | Tablet: 400 500 | 6–8 | 1200 | |
*Ketorolac tromethamine | Toradol | 100 | 5.2–5.6 | 10 | 4–6 | Age 17–65: 120 Age 65+: 60 Max 5 days | |
COX-2 selective | Celecoxib | Celebrex | N/A | 11 | 50 100 200 400 | 12 | 800 |
**Nimesulide | 54–64 | 1.8–4.7 | 100 | 12 | 200 Max 15 days | ||