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Table 1 Commonly prescribed NSAIDs and their pharmacology

From: Effect of non-steroidal anti-inflammatory drugs on post-surgical complications against the backdrop of the opioid crisis

Enzyme inhibited Name Bio-availability (%) Half-life (h) Dose (mg) Dosing interval (h) Max daily dose (mg)
Chemical Trade
COX-1 and COX-2 Aspirin   50–75 0.33 Enteric coated:
325
500
650
4 4000
Ibuprofen Advil
Motrin IB
80 2 200 4–6 1200
Diclofenac potassium Cambia
Cataplase
Zipsor
50–55 1–2 25
50
6–12 200
Indomethacin Tivorbex ~ 100 7.6 20
40
8–12 200
Naproxen Aleve
Naprosyn
95 12–17 375
500
6–8 1250
Piroxicam Feldene N/A 50 10
20
24 20
Etodolac Lodine 80 Tablet:
6.4
Tablet:
400
500
6–8 1200
*Ketorolac tromethamine Toradol 100 5.2–5.6 10 4–6 Age 17–65:
120
Age 65+:
60
Max 5 days
COX-2 selective Celecoxib Celebrex N/A 11 50
100
200
400
12 800
**Nimesulide   54–64 1.8–4.7 100 12 200
Max 15 days
  1. The values listed are for per oral (PO) formulation unless otherwise indicated. *Intravenous (IV) values shown; PO formula discontinued in the USA. **Not available in the USA. The majority of this table was compiled based on two online databases [57, 58], except data for nimesulide [59]. COX cyclooxygenase