Fig. 4

MDL28170 blunted (a) α-fodrin and (b) ankyrin-B degradation in the first hour after burn injury. The top image in each panel shows representative blots for the full-length and fragmented forms of α-fodrin and ankyrin-B. β-actin was used as a loading control. The bottom image in each panel shows the grouped results of the densitometric analysis. The values were expressed as arbitrary units relative to the sham group, which was assigned a value of 1. Each bar represents the mean ± SEM; n = 6 rats. ^##P < 0.01 vs sham. **P < 0.01 vs B-1 h. B-1 h, the samples were obtained at the first hour after scald burn. D3 stands for MDL28170 at a dose of 3 mg/kg b. w. MDL28170 was given intravenously 1 h before burn injury