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Fig. 6 | Burns & Trauma

Fig. 6

From: Calpain inhibition ameliorates scald burn-induced acute lung injury in rats

Fig. 6

MDL28170 reduced the number of calpain 1 and CD45 double-positive cells in the lung tissue of rats exposed to scald burn injury. a Representative immunofluorescence images in the sham, sham with MDL28170 (D3+Sham), burn injury (B-1 h), and burn injury with MDL28170 (D3+B-1 h) groups. The nuclei were counterstained with DAPI (blue). Arrows indicate the cells positive for calpain 1 and CD45 staining. Scale bar, 5 μm. b Grouped results of the positive cell numbers in a field of × 600 magnification. Each bar represents the mean ± SEM; n = 6 rats. ##P < 0.01 vs sham. **P < 0.01 vs B-1 h. B-1 h, the samples were obtained at 1 h after scald burn injury. D3 stands for MDL28170 at a dose of 3 mg/kg b. w. MDL28170 was given intravenously at a dosage of 3 mg/kg b. w. 1 h before burn injury

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