Fig. 2

A 72-year-old man presented with necrosis of 80% of the total dorsal area of his foot after a soft tissue infection due to uncontrolled diabetes mellitus. a Bare tendons of the dorsal foot defect after sharp debridement due to distal flap necrosis, and b application of leukocyte- and platelet-rich fibrin (L-PRF) over the defect. c After five applications of L-PRF, a small granulation tissue started to appear with viable exposed tendons. d Six weeks after the first application, the wound contracted and the formed granulation tissue almost covered the whole bare tendon at the medial side. e Eight weeks after the first application, the wound contracted and greater than 50% of the initial wound was epithelized. f After 18 weeks of L-PRF application, a completely healed complex wound was obtained with no complications