Table 2 Summary of findings for patient outcomes from qualitative and quantitative synthesis
Total number of patients | Debridement | Time to debridement, days Median (IQR) | Amputations Median (IQR) | Amputations (bones removed/transected) Median (IQR) | Time to amputation, days Median (IQR) | Reconstruction (grafts) | Reconstruction (flaps) | Time to reconstruction, days Median (IQR) | Hospital LOS, days Median (IQR) | Complications | Mortality | Time to mortality, days Median (IQR) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
190 | 71/190 cases | 12.5 (1.8–20.3) | •154/190 cases •Limbs involved = 4 (4–4) •BKA = 64 •AKA = 30 •Below-the-elbow = 28 •Above-the-elbow = 3 | 56 (9–84) | 18 (14–28) | •Total grafts = 33 •ADM = 3 •STSG = 13 •FTSG = 1 •Undifferentiated allografts = 5 •Undifferentiated autografts = 7 •Unknown = 4 | •Total flaps = 28 •Latissimus dorsi = 7 •Orbicularis oris = 4 •Serratus anterior = 2 •Posterolateral thigh = 1 •Free ALT = 1 •Free medial gastrocnemius = 1 •Gracilis = 1 •Internal island saphenous = 1 •Free forearm = 1 •Lateral arm = 1 •Forehead = 1 | 39 (23–56) | 57 (43.3–87.8) | •28/190 cases •Secondary infection = 20 •DVT/PE = 5 •Scarring = 5 •Wound contracture = 3 •Pressure ulcer = 1 •Wound breakdown = 1 •Alar stenosis = 1 •Facial deformity = 1 •Heterotopic ossification = 1 | 34/190 cases | 36 (26.3–72.8) |