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Table 2: Whole-blood GSH and plasma cysteine kinetics in sham burn and burned rabbits

From: Burn injury differentially alters whole-blood and organ glutathione synthesis rates: An experimental model

 

Sham

burn Burned

Body weight (kg)

2.7 ± 0.1

2.5 ± 0.1

Cysteine flux (μmol/kg/h)

29.3 ± 5.1

65.6 ± 8.9†

Increment of 13C-cysteine-GSH enrichment (molar ratio excess/min)

2.09 × 10−4

1.15 × 10−4†

FSRwb,gsh (per day)

0.46 ± 0.04

0.38 ± 0.02¥

Blood GSH concentration (μmol/l)

1486.0 ± 118.6

1263.8 ± 78.7§

Blood GSH synthesis rate (ASRwb,gsh, μmol/min/l)

666.7 ± 58.2

486.9 ± 41.6¶

  1. *Data are presented as Mean±SEM, sham burn n=7, burned n=6
  2. †Significantly different from sham burn animals, P<0.001 by unpaired t-test (equal variance)
  3. ¥Significantly different from sham burn animals, P<0.05 by unpaired t-test by Wilcox ranking test
  4. §Significantly different from sham burn animals, P=0.054 by unpaired t-test (equal variance)
  5. ¶Significantly different from sham burn animals, P<0.01 by Wilcox ranking test