Figure 6
From: Chronic allograft rejection: A significant hurdle to transplant success
RhoA/Rac1 pathways regulate actin dynamics. RhoA and its downstream effector ROCK, and their reciprocal interaction with Rac1, regulate (through actin-binding partners: Cofilin, myosin II, profilin, and vinculin) the pleiotropic actin-dependent processes pivotal for cell movement, phagocytosis, and cell differentiation. RhoA pathway inhibitors such as Y-27632, exoenzyme C3, and fasudil inhibit SMCs migration and may prevent chronic rejection-related vasculopathy.