Kidney histology in tissue from mice in either the MG53- or BSA-treated group (hematoxylin and eosin (HE) staining, ×400). (a) Healthy renal tissue. (b) Example of renal tissue from the BSA-treated group. Vacuolar degeneration and necrosis of kidney tubules was common (indicated by the arrow). (c) Example of kidney tissue from the MG53-treated group. These injuries were less severe than those observed in the BSA-treated group (indicated by the arrow). Scale bar denotes 100 µm. (d) Renal tissue damage scores of each group. The score of the MG53 group was 1.43 ± 0.19. The score of the BSA group was 2.67 ± 0.14 (P < 0.001).