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Table 1: Current success and challenges in VCA

From: Current status of vascularized composite tissue allotransplantation

Achievements Challenges
Excellent esthetic and functional outcome Minimization of immunosuppression, tolerance induction
Multidisciplinary approach Protocols for sensitized patients
Recognition as organ, regulated by OPTN Improved monitoring
Excellent patient and graft survival Mechanisms of rejection Acute cellular and humoral rejection
  Acute cellular and humoral rejection
  Chronic graft deterioration
  Nerve regeneration
  Definition of acceptable ischemic times
  Refined organ preservation
  1. VCA = Vascularized composite tissue allotransplantation, OPTN = Organ Procurement and Transplantation Network