Figure 2:
From: Current understanding of tyrosine kinase BMX in inflammation and its inhibitors
Role of bone marrow tyrosine kinase on chromosome X (BMX) in Toll-like receptor (TLR)4 signaling. BMX has been reported to interact with adaptor molecules (MyD88, or Mal) and transforming growth factor (TGF)-β activated kinase (TAK)1, leading to the activation of the NF-κB and MAPK-signaling pathways. This process results in inflammatory cytokine production. MD = myeloid differentiation protein, TRIF = Toll/interleukin-1 receptor domain-containing adaptor protein inducing interferon-β, TRAM = TRIF-related adaptor molecule, IRAK = interleukin-1 receptor-associated kinase, TRAF = TNF receptor-associated factor, MAPK = mitogen-activated protein kinases, IKK = inhibitor kappa B kinase, AP = activator protein.