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Table 1: Adhesion molecules involved in different stages of the classical neutrophil migration cascades in postcapillary venules

From: New strategy for sepsis: Targeting a key role of platelet-neutrophil interaction

Different stages

Molecules on endothelium

Molecules on neutrophil

Tethering and rolling

P-selectin

PSGL1 (positively regulates recruitment) PTX3 (negatively regulates recruitment)

Slow rolling

ICAM1

LFA1 (PSGL1-induced)

 

E-selectin

PSGL1, ESL1, CD44

Arrest and adhesion

ICAM1

LFA1

VCAM1

VLA4

Crawling

ICAM1

MAC1

Transmigration and diapedesis

ICAM1, ICAM2

LFA1, MAC1

VCAM1

VLA4

CD99

CD99

PECAM1

PECAM1

JAMA

LFA1, JAMA?

JAMB

VLA4

JAMC

MAC1

CD99L2

?

VE-cadherin (negatively regulates recruitment), ESAM

Between endothelial cells

  1. CD99L2 = CD99 antigen-like protein 2, ESAM = Endothelial cell-selective adhesion molecule, ESL1 = E-selectin ligand 1 (also known as GLG1), ICAM = Intercellular adhesion molecule, JAM = Junctional adhesion molecule, LFA1 = Lymphocyte function-associated antigen 1, PECAM1 = Platelet/endothelial cell adhesion molecule 1, PSGL1 = P selectin glycoprotein ligand 1, VCAM1 = Vascular cell adhesion protein 1, VE cadherin = Vascular endothelial cadherin, VLA4 = Very late antigen 4[36]