Skip to main content

Table 1: Adhesion molecules involved in different stages of the classical neutrophil migration cascades in postcapillary venules

From: New strategy for sepsis: Targeting a key role of platelet-neutrophil interaction

Different stages Molecules on endothelium Molecules on neutrophil
Tethering and rolling P-selectin PSGL1 (positively regulates recruitment) PTX3 (negatively regulates recruitment)
Slow rolling ICAM1 LFA1 (PSGL1-induced)
  E-selectin PSGL1, ESL1, CD44
Arrest and adhesion ICAM1 LFA1
VCAM1 VLA4
Crawling ICAM1 MAC1
Transmigration and diapedesis ICAM1, ICAM2 LFA1, MAC1
VCAM1 VLA4
CD99 CD99
PECAM1 PECAM1
JAMA LFA1, JAMA?
JAMB VLA4
JAMC MAC1
CD99L2 ?
VE-cadherin (negatively regulates recruitment), ESAM Between endothelial cells
  1. CD99L2 = CD99 antigen-like protein 2, ESAM = Endothelial cell-selective adhesion molecule, ESL1 = E-selectin ligand 1 (also known as GLG1), ICAM = Intercellular adhesion molecule, JAM = Junctional adhesion molecule, LFA1 = Lymphocyte function-associated antigen 1, PECAM1 = Platelet/endothelial cell adhesion molecule 1, PSGL1 = P selectin glycoprotein ligand 1, VCAM1 = Vascular cell adhesion protein 1, VE cadherin = Vascular endothelial cadherin, VLA4 = Very late antigen 4[36]