From: New strategy for sepsis: Targeting a key role of platelet-neutrophil interaction
Different stages | Molecules on endothelium | Molecules on neutrophil |
---|---|---|
Tethering and rolling | P-selectin | PSGL1 (positively regulates recruitment) PTX3 (negatively regulates recruitment) |
Slow rolling | ICAM1 | LFA1 (PSGL1-induced) |
 | E-selectin | PSGL1, ESL1, CD44 |
Arrest and adhesion | ICAM1 | LFA1 |
VCAM1 | VLA4 | |
Crawling | ICAM1 | MAC1 |
Transmigration and diapedesis | ICAM1, ICAM2 | LFA1, MAC1 |
VCAM1 | VLA4 | |
CD99 | CD99 | |
PECAM1 | PECAM1 | |
JAMA | LFA1, JAMA? | |
JAMB | VLA4 | |
JAMC | MAC1 | |
CD99L2 | ? | |
VE-cadherin (negatively regulates recruitment), ESAM | Between endothelial cells |