Table 1 Comparisons of cell types in native, engineered and grafted skin (adapted from [99])
From: Tissue engineering of skin and regenerative medicine for wound care
Tissue type | Cell type or structure | Uninjured skin | Split-thickness skin graft | Engineered skin substitutes | Healed skin after grafting |
|---|---|---|---|---|---|
Epidermis | Keratinocytes | + | + | + | + |
Hair follicle | + | − | − | − | |
Sebocytes | + | − | − | − | |
Sweat gland | + | − | − | − | |
Melanocytes | + | ± | ± | ± | |
Immune cells | + | + | − | + | |
Nerve | + | + | − | ± | |
Dermis | Fibroblasts | + | + | ± | + |
Endothelial cells | + | + | − | + | |
Extracellular matrix | + | ± | ± | ± | |
Smooth muscle | + | + | − | ± | |
Immune cells | + | + | − | + | |
Nerve | + | + | − | ± |