Articles

Development of a heart rate variability and complexity model in predicting the need for life-saving interventions amongst trauma patients

Triage trauma scores are utilised to determine patient disposition, interventions and prognostication in the care of trauma patients. Heart rate variability (HRV) and heart rate complexity (HRC) reflect the au...

Authors: Aravin Kumar, Nan Liu, Zhi Xiong Koh, Jayne Jie Yi Chiang, Yuda Soh, Ting Hway Wong, Andrew Fu Wah Ho, Takashi Tagami, Stephanie Fook-Chong and Marcus Eng Hock Ong

Advances in surgical applications of growth factors for wound healing

Growth factors have recently gained clinical importance for wound management. Application of recombinant growth factors has been shown to mimic cell migration, proliferation, and differentiation in vivo, allowing...

Authors: Sho Yamakawa and Kenji Hayashida

Burn recidivism: a 10-year retrospective study characterizing patients with repeated burn injuries at a large tertiary referral burn center in the United States

Psychiatric and substance use disorders are common among trauma and burn patients and are known risk factors for repeat episodes of trauma, known as trauma recidivism. The epidemiology of burn recidivism, spec...

Authors: Sarah L. Laughon, Bradley N. Gaynes, Lori P. Chrisco, Samuel W. Jones, Felicia N. Williams, Bruce A. Cairns and Gary J. Gala

Cardiac proteomics reveals the potential mechanism of microtubule associated protein 4 phosphorylation-induced mitochondrial dysfunction

Our previous work suggested that microtubule associated protein 4 (MAP4) phosphorylation led to mitochondrial dysfunction in MAP4 phosphorylation mutant mice with cardiomyopathy, but the detailed mechanism was...

Authors: Lingfei Li, Junhui Zhang, Qiong Zhang, Yuesheng Huang and Jiongyu Hu

Surgery for scar revision and reduction: from primary closure to flap surgery

Scars are the final result of the four processes that constitute cutaneous wound healing, namely, coagulation, inflammation, proliferation, and remodeling. Permanent scars are produced if the wounds reach the ...

Authors: Rei Ogawa

Burn image segmentation based on Mask Regions with Convolutional Neural Network deep learning framework: more accurate and more convenient

Burns are life-threatening with high morbidity and mortality. Reliable diagnosis supported by accurate burn area and depth assessment is critical to the success of the treatment decision and, in some cases, ca...

Authors: Chong Jiao, Kehua Su, Weiguo Xie and Ziqing Ye

The 1470 nm diode laser with an intralesional fiber device: a proposed solution for the treatment of inflamed and infected keloids

Keloids are the result of abnormal wound healing and often are subject to infections and recurrent inflammation. We present a study conducted with a 1470 nm diode laser using an intralesional optical fiber dev...

Authors: Ke Li, Fabio Nicoli, Wen Jing Xi, Zheng Zhang, Chunxiao Cui, Ahmed Al-Mousawi, Alberto Balzani, Yun Tong and Yixin Zhang

Skin bioprinting: the future of burn wound reconstruction?

Burns are a significant cause of trauma, and over the years, the focus of patient care has shifted from just survival to facilitation of improved functional outcomes. Typically, burn treatment, especially in t...

Authors: Mathew Varkey, Dafydd O. Visscher, Paul P. M. van Zuijlen, Anthony Atala and James J. Yoo

Advances in the treatment of traumatic scars with laser, intense pulsed light, radiofrequency, and ultrasound

Traumatic scarring is one of the most common complications after soft tissue injury caused by burns and trauma, which affects tens of millions of people worldwide every year. Traumatic scars diminish the quali...

Authors: Xiujun Fu, Jiying Dong, Shen Wang, Min Yan and Min Yao

Survival analysis and mortality predictors of hospitalized severe burn victims in a Malaysian burns intensive care unit

Prognostic measures to determine burn mortality are essential in evaluating the severity of individual burn victims. This is an important process of triaging patients with high risk of mortality that may be nu...

Authors: Henry Tan Chor Lip, Jih Huei Tan, Mathew Thomas, Farrah-Hani Imran and Tuan Nur’ Azmah Tuan Mat

Development and use of biomaterials as wound healing therapies

There is a vast number of treatments on the market for the management of wounds and burns, representing a multi-billion dollar industry worldwide. These include conventional wound dressings, dressings that inc...

Authors: Rachael Zoe Murray, Zoe Elizabeth West, Allison June Cowin and Brooke Louise Farrugia

Recent advances of on-demand dissolution of hydrogel dressings

Wound management is a major global challenge and a big financial burden to the healthcare system due to the rapid growth of chronic diseases including the diabetes, obesity, and aging population. Modern soluti...

Authors: Hao Lu, Long Yuan, Xunzhou Yu, Chengzhou Wu, Danfeng He and Jun Deng

Human acellular amniotic membrane implantation for lower third nasal reconstruction: a promising therapy to promote wound healing

The lower third of the nose is one of the most important cosmetic units of the face, and its reconstructive techniques remain a big challenge. As an alternative approach to repair or regenerate the nasal tissu...

Authors: Si-Liang Xue, Kai Liu, Ornella Parolini, Yue Wang, Li Deng and Yong-Can Huang

Prospective randomised controlled trial of Algisite™ M, Cuticerin™, and Sorbact® as donor site dressings in paediatric split-thickness skin grafts

This is a parallel three-arm prospective randomised controlled trial (RCT) comparing Algisite™ M, Cuticerin™, and Sorbact® as donor site dressings in paediatric split-thickness skin grafts (STSG). All three we...

Authors: Craig A. McBride, Roy M. Kimble and Kellie A. Stockton

Long-term mental health outcomes after unintentional burns sustained during childhood: a retrospective cohort study

Burns are a devastating injury that can cause physical and psychological issues. Limited data exist on long-term mental health (MH) after unintentional burns sustained during childhood. This study assessed lon...

Authors: Janine M. Duke, Sean M. Randall, Thirthar P. Vetrichevvel, Sarah McGarry, James H. Boyd, Suzanne Rea and Fiona M. Wood

A population-based comparison study of the mental health of patients with intentional and unintentional burns

A number of studies report high prevalence of mental health conditions among burn patients. However there is a need to understand differences in the temporal relationship between mental health conditions and i...

Authors: Thirthar P Vetrichevvel, Sean M Randall, Fiona M Wood, Suzanne Rea, James H Boyd and Janine M Duke

Valuable prognostic indicators for severe burn sepsis with inhalation lesion: age, platelet count, and procalcitonin

Severe burn sepsis can lead to high mortality. We explored the valuable prognostic indicators for severe burn sepsis with inhalation lesion.

Authors: Yichao Xu, Xinyuan Jin, Xiaonan Shao, Feng Zheng and Hong Zhou

Weight changes and patterns of weight measurements in hospitalized burn patients: a contemporary analysis

Severe burn is associated with significant changes in body weight due to resuscitation volumes, fluid shifts, a hypermetabolic state, prolonged bed rest, and caloric intake. Our goal was to quantify and descri...

Authors: Denisse Mendez-Romero, Audra T Clark, Alana Christie and Steven E Wolf

Calpain inhibition ameliorates scald burn-induced acute lung injury in rats

The molecular pattern of severe burn-induced acute lung injury, characterized by cell structure damage and leukocyte infiltration, remains unknown. This study aimed to determine whether calpain, a protease inv...

Authors: Peng-Ran Du, Hong-Ting Lu, Xi-Xiang Lin, Li-Feng Wang, Yan-Xia Wang, Xiao-Ming Gu, Xiao-Zhi Bai, Ke Tao and Jing-Jun Zhou

Chinese expert consensus on clinical prevention and treatment of scar⁺

Following injury, Asian skin has a tendency toward hyperpigmentation and scar formation than Caucasians. A standardized algorithm tailored to Asian patients, especially Chinese patients, is in great demand. Tw...

Authors: Kaiyang Lv and Zhaofan Xia

Effect of non-steroidal anti-inflammatory drugs on post-surgical complications against the backdrop of the opioid crisis

The USA is currently going through an opioid crisis, associated with tremendous economic and societal impacts. In response to this crisis, healthcare professionals are looking for alternative pain management m...

Authors: Hannah Zhao-Fleming, Audrey Hand, Kelly Zhang, Robert Polak, Armand Northcut, Daron Jacob, Sharmila Dissanaike and Kendra P. Rumbaugh

Quantifying the impact of inhalational burns: a prospective study

Inhalational injury is a major cause of morbidity and mortality in burns patients. This study aims to analyse the clinical outcomes, complications and bacteriology of inhalational burn patients.

Authors: Si Jack Chong, Yee Onn Kok, Rosanna Xiang Ying Tay, Desai Suneel Ramesh, Kok Chai Tan and Bien Keem Tan

Multi-institutional analysis of independent predictors for burn mortality in the United States

Previous reports individually identified different factors that predict death after burns. The authors employed the multi-center American Burn Association’s (ABA) National Burn Repository (NBR) to elucidate wh...

Authors: Dmitry Zavlin, Vishwanath Chegireddy, Stefanos Boukovalas, Anna M. Nia, Ludwik K. Branski, Jeffrey D. Friedman and Anthony Echo

Are there any differences in the provided burn care between men and women? A retrospective study

Disparity between medical treatment for men and women has been recorded worldwide. However, it is difficult to find out if the disparities in both the use of resources and outcome depend entirely on sex-relate...

Authors: Laura Pompermaier, Moustafa Elmasry, Islam Abdelrahman, Mats Fredrikson, Folke Sjöberg and Ingrid Steinvall

Ultrasonographic findings of re-epithelialized skin after partial-thickness burns

This study aimed to investigate the difference between ultrasonographic findings of normal skin and those of re-epithelialized skin after partial-thickness burns and to evaluate the relationship between these ...

Authors: Jong Dae Kim, Suk Joon Oh, Sun Gyu Kim, Song Vogue Ahn, Yu Jin Jang, Ban Seok Yang, Ji Yun Jeong and Kwang Jo Kim

Distraction ligamentotaxis for complex proximal interphalangeal joint fracture dislocations: a clinical study and the modified pins rubber band traction system revisited

The purpose of this study is to present our experience with the modified pins and rubber band traction system, discuss problems encountered, and make recommendations to optimize outcomes.

Authors: Cheng Hean Lo, Simone H. Nothdurft, Hye-Sung Park, Eldho Paul and James Leong

Electrically stimulated cell migration and its contribution to wound healing

Naturally occurring electric fields are known to be morphogenetic cues and associated with growth and healing throughout mammalian and amphibian animals and the plant kingdom. Electricity in animals was discov...

Authors: Guangping Tai, Michael Tai and Min Zhao

Review of additive manufactured tissue engineering scaffolds: relationship between geometry and performance

Material extrusion additive manufacturing has rapidly grown in use for tissue engineering research since its adoption in the year 2000. It has enabled researchers to produce scaffolds with intricate porous geo...

Authors: Andrew Gleadall, Dafydd Visscher, Jing Yang, Daniel Thomas and Joel Segal

The venous ulcer continues to be a clinical challenge: an update

Venous ulcers are a common chronic problem in many countries especially in Northern Europe and USA. The overall prevalence of this condition is 1% rising to 3% in the over 65 years of age. Over the last 25 yea...

Authors: Ting Xie, Junna Ye, Kittipan Rerkasem and Rajgopal Mani

A retrospective cohort study to compare post-injury admissions for infectious diseases in burn patients, non-burn trauma patients and uninjured people

Injury triggers a range of systemic effects including inflammation and immune responses. This study aimed to compare infectious disease admissions after burn and other types of injury using linked hospital adm...

Authors: Janine M. Duke, Sean M. Randall, James H. Boyd, Mark W. Fear, Suzanne Rea and Fiona M. Wood

3D printing of patient-specific neck splints for the treatment of post-burn neck contractures

Authors: Dafydd O. Visscher, Sjoerd te Slaa, Mariëlle E. Jaspers, Marloes van de Hulsbeek, Jorien Borst, Jan Wolff, Tymour Forouzanfar and Paul P. van Zuijlen

Cell therapy for severe burn wound healing

Cell therapy has emerged as an important component of life-saving procedures in treating burns. Over past decades, advances in stem cells and regenerative medicine have offered exciting opportunities of develo...

Authors: Zhe Li and Peter Maitz

Epidemiologic and clinical characteristics of severe burn patients: results of a retrospective multicenter study in China, 2011–2015

Severe burns injury is a serious pathology, leading to teratogenicity and significant mortality, and it also has a long-term social impact. The aim of this article is to describe the hospitalized population wi...

Authors: Hao Tian, Liangxi Wang, Weiguo Xie, Chuanan Shen, Guanghua Guo, Jiaqi Liu, Chunmao Han, Licheng Ren, Yi Liang, Yong Tang, Yuan Wang, Meifang Yin, Jiaping Zhang and Yuesheng Huang

Synthesis of graphene oxide-quaternary ammonium nanocomposite with synergistic antibacterial activity to promote infected wound healing

Bacterial infection is one of the most common complications in burn, trauma, and chronic refractory wounds and is an impediment to healing. The frequent occurrence of antimicrobial-resistant bacteria due to ir...

Authors: Tengfei Liu, Yuqing Liu, Menglong Liu, Ying Wang, Weifeng He, Gaoqiang Shi, Xiaohong Hu, Rixing Zhan, Gaoxing Luo, Malcolm Xing and Jun Wu

Body image in paediatric burns: a review

Burn injuries in children can result in life-long disfigurement. As medical and surgical techniques of burn management improve survival prospects more than ever before, body image adjustment is increasingly a ...

Authors: Ian C. C. King

Vitamin D status and its influence on outcomes following major burn injury and critical illness

Vitamin D deficiency is common among the general population. It is also observed in up to 76% of critically ill patients. Despite the high prevalence of hypovitaminosis D in critical illness, vitamin D is ofte...

Authors: Khaled Al-Tarrah, Martin Hewison, Naiem Moiemen and Janet M. Lord

Mental health history—a contributing factor for poorer outcomes in burn survivors

A pre-morbid mental health history is common in patients with severe burn injuries. This creates challenges in providing rehabilitation. The aim of this study is to cross examine the possible impact of psychol...

Authors: Frank Li and Danielle Coombs

Checking procalcitonin suitability for prognosis and antimicrobial therapy monitoring in burn patients

Due to greater infection susceptibility, sepsis is the main cause of death in burn patients. Quick diagnosis and patient stratification, early and appropriated antimicrobial therapy, and focus control are cruc...

Authors: Luís Cabral, Vera Afreixo, Rita Meireles, Miguel Vaz, Catarina Chaves, Marisa Caetano, Luís Almeida and José Artur Paiva

Assessment and prediction of road accident injuries trend using time-series models in Kurdistan

Road traffic accidents are commonly encountered incidents that can cause high-intensity injuries to the victims and have direct impacts on the members of the society. Iran has one of the highest incident rates...

Authors: Maryam Parvareh, Asrin Karimi, Satar Rezaei, Abraha Woldemichael, Sairan Nili, Bijan Nouri and Nader Esmail Nasab

A rare case of severe third degree friction burns and large Morel-Lavallee lesion of the abdominal wall

Morel-Lavallee lesions (MLLs) are rare internal degloving injuries typically caused by blunt traumatic injuries and most commonly occur around the hips and in association with pelvic or acetabular fractures. M...

Authors: Darnell J. Brown, Kuo Jung G. Lu, Kristina Chang, Jennifer Levin, John T. Schulz III and Jeremy Goverman

The validation study on a three-dimensional burn estimation smart-phone application: accurate, free and fast?

Accurate total body surface area burned (TBSAB) estimation is a crucial aspect of early burn management. It helps guide resuscitation and is essential in the calculation of fluid requirements. Conventional met...

Authors: A. K. W. Cheah, T. Kangkorn, E. H. Tan, M. L. Loo and S. J. Chong

Post-traumatic stress disorder and resilience among adult burn patients in Pakistan: a cross-sectional study

Post-traumatic stress disorder (PTSD) is one of the major psychological disorders developed after burn injuries, though this subject of burn injuries and their destructive chronic psychological impact are not ...

Authors: Akhtar Bibi, Sundas Kalim and Muhammad Adnan Khalid

Free-style puzzle flap as a cross-leg pedicled flap: the concept of re-using a flap in acute burns, a case report

In well-selected cases, flaps can play a pivotal role in optimizing outcomes in the acute phase of burns. A previous redundant flap could be reused or recycled as a donor site from which a new flap could be ra...

Authors: Kevin Serror, Marc Chaouat, Golda Romano, Magali Schmidt, Alice Blet, Maurice Mimoun and David Boccara

Tissue engineering of skin and regenerative medicine for wound care

Engineering of biologic skin substitutes has progressed over time from individual applications of skin cells, or biopolymer scaffolds, to combinations of cells and scaffolds for treatment, healing, and closure...

Authors: Steven T. Boyce and Andrea L. Lalley

Bioprinting of skin constructs for wound healing

Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissue...

Authors: Peng He, Junning Zhao, Jiumeng Zhang, Bo Li, Zhiyuan Gou, Maling Gou and Xiaolu Li

An objective measure for the assessment and management of fluid shifts in acute major burns

Major burns are life threatening. Fluid resuscitation is required for survival to maintain intravascular volumes and prevent hypovolemic shock. Bioimpedance spectroscopy (BIS) has been recognised as a potentia...

Authors: Pippa Kenworthy, Michael Phillips, Tiffany L. Grisbrook, William Gibson, Fiona M. Wood and Dale W. Edgar

Validation of the trauma mortality prediction scores from a Malaysian population

Well-known trauma mortality prediction scores such as New Injury Severity Score (NISS), Revised Trauma Score (RTS), and Trauma and Injury Severity Score (TRISS) have been externally validated from high-income ...

Authors: Jih Huei Tan, Henry Chor Lip Tan, Nur Azlin Md Noh, Yuzaidi Mohamad and Rizal Imran Alwi

The significance of changes in platelet concentration during the early phase after severe burn injury in a Chinese mass casualty

Changes in platelet concentration are common in severe burn patients. Platelets play a key role in the course of disease. This study aims to explore the significance of platelet concentration during the course...

Authors: Beiming Shou, Junqiang Li, Chenqi Tang, Qian Tan, Dongfeng Zheng, Binwei Sun, Lanjun Nie, Hongwei Zhang, Yanan Jiang, Chunming Wang and Yanwen Wu

A rare case of failed healing in previously burned skin after a secondary burns

Patients presenting with large surface area burns are common in our practice; however, patients with a secondary large burn on pre-existing burn scars and grafts are rare and not reported.

Authors: Stephen J. Goldie, Shaun Parsons, Hana Menezes, Andrew Ives and Heather Cleland

Follow-up in patients with a burn-related emergency department visit: a feasibility study

Data on epidemiology, costs, and outcomes of burn-related injuries presenting at emergency departments (EDs) are scarce. To obtain such information, a questionnaire study with an adequate response rate is impe...

Authors: H. Goei, B. F. M. Wijnen, S. Mans, M. A. C. de Jongh, C. H. van der Vlies, S. Polinder, N. E. E. van Loey and M. E. van Baar