Articles

Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018

There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic d...

Authors: Rei Ogawa, Sadanori Akita, Satoshi Akaishi, Noriko Aramaki-Hattori, Teruyuki Dohi, Toshihiko Hayashi, Kazuo Kishi, Taro Kono, Hajime Matsumura, Gan Muneuchi, Naoki Murao, Munetomo Nagao, Keisuke Okabe, Fumiaki Shimizu, Mamiko Tosa, Yasuyoshi Tosa…

Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration

Cutaneous regeneration at the wound site involves several intricate and dynamic processes which require a series of coordinated interactions implicating various cell types, growth factors, extracellular matrix...

Authors: Peng Hu, Qinxin Yang, Qi Wang, Chenshuo Shi, Dali Wang, Ubaldo Armato, Ilaria Dal Prà and Anna Chiarini

Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model

The intestinal barrier integrity can be disrupted due to burn injury, which is responsible for local and systemic inflammatory responses. Anti-inflammation strategy is one of the proposed therapeutic approache...

Authors: Yajun Song, Yang Li, Ya Xiao, Wengang Hu, Xu Wang, Pei Wang, Xiaorong Zhang, Jiacai Yang, Yong Huang, Weifeng He and Chibing Huang

A case of scalp avulsion with prolonged ischemic time: indocyanine green angiography can aid in predicting replant survival

Microsurgical replantation has become the most favorable treatment option for scalp avulsion. However, the accurate prediction of postoperative replant viability remains challenging.

Authors: Xin Huang, Zhichao Wang, Caiyue Liu, Shuchen Gu, Yashan Gao, Xiangwen Xu and Tao Zan

Investigating clinical characteristics and prognostic factors in patients with chronic osteomyelitis of humerus

Chronic osteomyelitis in the humerus, which has complex neuroanatomy and a good soft tissue envelope, represents a unique clinical challenge. However, there are relatively few related studies in the literature...

Authors: Hongri Wu, Shengpeng Yu, Jingshu Fu, Dong Sun, Shulin Wang, Zhao Xie and Yungui Wang

Correction to: Abstracts from the 12th Asia Pacific Burn Congress

Following publication of the supplement Abstracts from the 12th Asia Pacific Burn Congress [1], all affiliations have been revised for legal reasons.

Authors:

Analysis of t-test misuses and SPSS operations in medical research papers

Authors: Guangping Liang, Wenliang Fu and Kaifa Wang

Extracorporeal membrane oxygenation for acute respiratory distress syndrome in burn patients: a case series and literature update

Acute respiratory distress syndrome (ARDS) has a reported incidence of 34–43% in ventilated burn patients and is associated with a mortality of 59% in the severe form. The use and experience with extracorporea...

Authors: Mehran Dadras, Johannes M. Wagner, Christoph Wallner, Julika Huber, Dirk Buchwald, Justus Strauch, Kamran Harati, Nicolai Kapalschinski, Björn Behr and Marcus Lehnhardt

Comparative effectiveness of Biobrane®, RECELL® Autologous skin Cell suspension and Silver dressings in partial thickness paediatric burns: BRACS randomised trial protocol

Mixed partial thickness burns are the most common depth of burn injury managed at a large Australian paediatric hospital specialty burns unit. Prolonged time until re-epithelialisation is associated with incre...

Authors: Anjana Bairagi, Bronwyn Griffin, Zephanie Tyack, Dimitrios Vagenas, Steven M. McPhail and Roy Kimble

“Streets of Fire” revisited: contact burns

Pavement-street contact burns are rare. This study compared recent contact burns to those published in “Pavement temperature and burns: Streets of Fire” in 1995. The hypothesis was that there were a significan...

Authors: Areta Kowal-Vern, Marc R. Matthews, Karen N. Richey, Kathy Ruiz, Michael Peck, Arpana Jain and Kevin N. Foster

Surgical outcomes in adults with purpura fulminans: a systematic review and patient-level meta-synthesis

Cutaneous manifestations of purpura fulminans (PF) present many challenges for clinicians and surgeons. In a state of septic shock complicated by limb ischemia, surgical interventions are necessary to control ...

Authors: Kevin M. Klifto, Caresse F. Gurno, Michael J. Grzelak, Stella M. Seal, Mohammed Asif, C. Scott Hultman and Julie A. Caffrey

Redirecting differentiation of mammary progenitor cells by 3D bioprinted sweat gland microenvironment

Mammary progenitor cells (MPCs) maintain their reproductive potency through life, and their specific microenvironments exert a deterministic control over these cells. MPCs provides one kind of ideal tools for ...

Authors: Rui Wang, Yihui Wang, Bin Yao, Tian Hu, Zhao Li, Yufan Liu, Xiaoli Cui, Liuhanghang Cheng, Wei Song, Sha Huang and Xiaobing Fu

Understanding acute burn injury as a chronic disease

While treatment for burn injury has improved significantly over the past few decades, reducing mortality and improving patient outcomes, recent evidence has revealed that burn injury is associated with a numbe...

Authors: Lucy W. Barrett, Vanessa S. Fear, Jason C. Waithman, Fiona M. Wood and Mark W. Fear

Acute surgical vs non-surgical management for ocular and peri-ocular burns: a systematic review and meta-analysis

Burn-related injury to the face involving the structures of the eyes, eyelids, eyelashes, and/or eyebrows could result in multiple reconstructive procedures to improve functional and cosmetic outcomes, and cor...

Authors: Kevin M. Klifto, Ala Elhelali, Caresse F. Gurno, Stella M. Seal, Mohammed Asif and C. Scott Hultman

Abstracts from the 12th Asia Pacific Burn Congress

Authors:

One-step approach for full-thickness skin defect reconstruction in rats using minced split-thickness skin grafts with Pelnac overlay

Split-thickness skin grafting is the current gold standard for the treatment of traumatic skin loss. However, for patients with extensive burns, split-thickness skin grafting is limited by donor skin availabil...

Authors: Tong Liu, Chao Qiu, Chi Ben, Haihang Li and Shihui Zhu

Optimized clinical practice for superaged patients with hip fracture: significance of damage control and enhanced recovery program

With the advent of global aging, the incidence, mortality, and medical costs of hip fracture among aged patients are increasing annually. The number of controlled clinical studies and health economics analyses...

Authors: Zaiyang Liu, Jun Zhang, Kaiqi He, Yumei Zhang and Yuan Zhang

Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient

Severe injuries are the major cause of death in those aged under 40, mainly due to road traffic collisions. Endocrine, metabolic and immune pathways respond to limit the tissue damage sustained and initiate wo...

Authors: Conor Bentley, Jon Hazeldine, Carolyn Greig, Janet Lord and Mark Foster

Intestinal barrier dysfunction in severe burn injury

Severe burn injury is often accompanied by intestinal barrier dysfunction, which is closely associated with post-burn shock, bacterial translocation, systemic inflammatory response syndrome, hypercatabolism, s...

Authors: Wen He, Yu Wang, Pei Wang and Fengjun Wang

Timely completion of multiple life-saving interventions for traumatic haemorrhagic shock: a retrospective cohort study

Early control of haemorrhage and optimisation of physiology are guiding principles of resuscitation after injury. Improved outcomes have been previously associated with single, timely interventions. The aim of...

Authors: Biswadev Mitra, Jordan Bade-Boon, Mark C. Fitzgerald, Ben Beck and Peter A. Cameron

Severe burn injury alters intestinal microbiota composition and impairs intestinal barrier in mice

The intestinal barrier integrity is crucial for maintaining intestinal homeostasis, and the mechanisms of intestinal barrier disruption induced by burn injury remain obscure. This study was aimed to investigat...

Authors: Yanhai Feng, Yalan Huang, Yu Wang, Pei Wang and Fengjun Wang

Stevens-Johnson Syndrome complicated by obstructive uropathy, pneumothorax, and pneumomediastinum: a case report and literature review

Stevens-Johnson Syndrome (SJS) is an acute mucocutaneous eruption with blisters of the skin and haemorrhagic erosions of mucous membranes. This report describes air-leak syndrome and obstructive uropathy occur...

Authors: Damian Bruce-Hickman, Xiao Jiang, Joshua Jin-Ping Thia and Amit Kansal

Substance use and inhalation injury in adult burn patients: retrospective study of the impact on outcomes

Substance use, alcohol use, and smoking use have all been associated with burn injury. Few studies have investigated associations with substances, alcohol, smoking, inhalational only burns, and patient outcome...

Authors: Kevin M. Klifto, Luis Quiroga and C. Scott Hultman

Iatrogenic wounds: a common but often overlooked problem

Iatrogenic wounds are a common but often overlooked concept. They can lead to increases in hospital stays, therapy costs, repeat surgeries, and implant removal. If not handled properly, these wounds have a ver...

Authors: Biao Cheng, Ju Tian, Yan Peng and Xiaobing Fu

Tumor necrosis factor receptor-associated protein 1 regulates hypoxia-induced apoptosis through a mitochondria-dependent pathway mediated by cytochrome c oxidase subunit II

Tumor necrosis factor receptor-associated protein 1 (TRAP1) plays a protective effect in hypoxic cardiomyocytes, but the precise mechanisms are not well clarified. The study is aimed to identify the mechanism ...

Authors: Fei Xiang, Si-yuan Ma, Yan-ling Lv, Dong-xia Zhang, Hua-pei Song and Yue-sheng Huang

Joint contractures in severe burn patients with early rehabilitation intervention in one of the largest burn intensive care unit in China: a descriptive analysis

Joint contracture is the major clinical complication in burn patients, especially, the severe burn patients. This study aimed to investigate the number and severity of joint contractures in patients with burns...

Authors: Jianglin Tan, Jian Chen, Junyi Zhou, Huapei Song, Huan Deng, Ming Ao, Gaoxing Luo and Jun Wu

Leucocyte- and platelet-rich fibrin as a rescue therapy for small-to-medium-sized complex wounds of the lower extremities

Generally, advanced wound care resources are applied for complex wounds that pose a challenge to the medical and nursing teams. In this report, the use of leukocyte- and platelet-rich fibrin (L-PRF) is emphasi...

Authors: Kadri Ozer and Ozlem Colak

Hypocoagulation induced by broad-spectrum antibiotics in extensive burn patients

Patients with extensive burns usually develop pro-coagulation soon after the injury if there is no sepsis occurred. We describe the case of an extensive burn adult suffering from hypocoagulation not related to...

Authors: Jian Liu, Yiqing Liu, Shengjun Liu, Qin Zhang, Jiexin Zheng, Yiwen Niu and Xuefeng Wang

Development of a heart rate variability and complexity model in predicting the need for life-saving interventions amongst trauma patients

Triage trauma scores are utilised to determine patient disposition, interventions and prognostication in the care of trauma patients. Heart rate variability (HRV) and heart rate complexity (HRC) reflect the au...

Authors: Aravin Kumar, Nan Liu, Zhi Xiong Koh, Jayne Jie Yi Chiang, Yuda Soh, Ting Hway Wong, Andrew Fu Wah Ho, Takashi Tagami, Stephanie Fook-Chong and Marcus Eng Hock Ong

Advances in surgical applications of growth factors for wound healing

Growth factors have recently gained clinical importance for wound management. Application of recombinant growth factors has been shown to mimic cell migration, proliferation, and differentiation in vivo, allowing...

Authors: Sho Yamakawa and Kenji Hayashida

Burn recidivism: a 10-year retrospective study characterizing patients with repeated burn injuries at a large tertiary referral burn center in the United States

Psychiatric and substance use disorders are common among trauma and burn patients and are known risk factors for repeat episodes of trauma, known as trauma recidivism. The epidemiology of burn recidivism, spec...

Authors: Sarah L. Laughon, Bradley N. Gaynes, Lori P. Chrisco, Samuel W. Jones, Felicia N. Williams, Bruce A. Cairns and Gary J. Gala

Cardiac proteomics reveals the potential mechanism of microtubule associated protein 4 phosphorylation-induced mitochondrial dysfunction

Our previous work suggested that microtubule associated protein 4 (MAP4) phosphorylation led to mitochondrial dysfunction in MAP4 phosphorylation mutant mice with cardiomyopathy, but the detailed mechanism was...

Authors: Lingfei Li, Junhui Zhang, Qiong Zhang, Yuesheng Huang and Jiongyu Hu

Surgery for scar revision and reduction: from primary closure to flap surgery

Scars are the final result of the four processes that constitute cutaneous wound healing, namely, coagulation, inflammation, proliferation, and remodeling. Permanent scars are produced if the wounds reach the ...

Authors: Rei Ogawa

Burn image segmentation based on Mask Regions with Convolutional Neural Network deep learning framework: more accurate and more convenient

Burns are life-threatening with high morbidity and mortality. Reliable diagnosis supported by accurate burn area and depth assessment is critical to the success of the treatment decision and, in some cases, ca...

Authors: Chong Jiao, Kehua Su, Weiguo Xie and Ziqing Ye

The 1470 nm diode laser with an intralesional fiber device: a proposed solution for the treatment of inflamed and infected keloids

Keloids are the result of abnormal wound healing and often are subject to infections and recurrent inflammation. We present a study conducted with a 1470 nm diode laser using an intralesional optical fiber dev...

Authors: Ke Li, Fabio Nicoli, Wen Jing Xi, Zheng Zhang, Chunxiao Cui, Ahmed Al-Mousawi, Alberto Balzani, Yun Tong and Yixin Zhang

Skin bioprinting: the future of burn wound reconstruction?

Burns are a significant cause of trauma, and over the years, the focus of patient care has shifted from just survival to facilitation of improved functional outcomes. Typically, burn treatment, especially in t...

Authors: Mathew Varkey, Dafydd O. Visscher, Paul P. M. van Zuijlen, Anthony Atala and James J. Yoo

Advances in the treatment of traumatic scars with laser, intense pulsed light, radiofrequency, and ultrasound

Traumatic scarring is one of the most common complications after soft tissue injury caused by burns and trauma, which affects tens of millions of people worldwide every year. Traumatic scars diminish the quali...

Authors: Xiujun Fu, Jiying Dong, Shen Wang, Min Yan and Min Yao

Survival analysis and mortality predictors of hospitalized severe burn victims in a Malaysian burns intensive care unit

Prognostic measures to determine burn mortality are essential in evaluating the severity of individual burn victims. This is an important process of triaging patients with high risk of mortality that may be nu...

Authors: Henry Tan Chor Lip, Jih Huei Tan, Mathew Thomas, Farrah-Hani Imran and Tuan Nur’ Azmah Tuan Mat

Development and use of biomaterials as wound healing therapies

There is a vast number of treatments on the market for the management of wounds and burns, representing a multi-billion dollar industry worldwide. These include conventional wound dressings, dressings that inc...

Authors: Rachael Zoe Murray, Zoe Elizabeth West, Allison June Cowin and Brooke Louise Farrugia

Recent advances of on-demand dissolution of hydrogel dressings

Wound management is a major global challenge and a big financial burden to the healthcare system due to the rapid growth of chronic diseases including the diabetes, obesity, and aging population. Modern soluti...

Authors: Hao Lu, Long Yuan, Xunzhou Yu, Chengzhou Wu, Danfeng He and Jun Deng

Human acellular amniotic membrane implantation for lower third nasal reconstruction: a promising therapy to promote wound healing

The lower third of the nose is one of the most important cosmetic units of the face, and its reconstructive techniques remain a big challenge. As an alternative approach to repair or regenerate the nasal tissu...

Authors: Si-Liang Xue, Kai Liu, Ornella Parolini, Yue Wang, Li Deng and Yong-Can Huang

Prospective randomised controlled trial of Algisite™ M, Cuticerin™, and Sorbact® as donor site dressings in paediatric split-thickness skin grafts

This is a parallel three-arm prospective randomised controlled trial (RCT) comparing Algisite™ M, Cuticerin™, and Sorbact® as donor site dressings in paediatric split-thickness skin grafts (STSG). All three we...

Authors: Craig A. McBride, Roy M. Kimble and Kellie A. Stockton

Long-term mental health outcomes after unintentional burns sustained during childhood: a retrospective cohort study

Burns are a devastating injury that can cause physical and psychological issues. Limited data exist on long-term mental health (MH) after unintentional burns sustained during childhood. This study assessed lon...

Authors: Janine M. Duke, Sean M. Randall, Thirthar P. Vetrichevvel, Sarah McGarry, James H. Boyd, Suzanne Rea and Fiona M. Wood

A population-based comparison study of the mental health of patients with intentional and unintentional burns

A number of studies report high prevalence of mental health conditions among burn patients. However there is a need to understand differences in the temporal relationship between mental health conditions and i...

Authors: Thirthar P Vetrichevvel, Sean M Randall, Fiona M Wood, Suzanne Rea, James H Boyd and Janine M Duke

Valuable prognostic indicators for severe burn sepsis with inhalation lesion: age, platelet count, and procalcitonin

Severe burn sepsis can lead to high mortality. We explored the valuable prognostic indicators for severe burn sepsis with inhalation lesion.

Authors: Yichao Xu, Xinyuan Jin, Xiaonan Shao, Feng Zheng and Hong Zhou

Weight changes and patterns of weight measurements in hospitalized burn patients: a contemporary analysis

Severe burn is associated with significant changes in body weight due to resuscitation volumes, fluid shifts, a hypermetabolic state, prolonged bed rest, and caloric intake. Our goal was to quantify and descri...

Authors: Denisse Mendez-Romero, Audra T Clark, Alana Christie and Steven E Wolf

Calpain inhibition ameliorates scald burn-induced acute lung injury in rats

The molecular pattern of severe burn-induced acute lung injury, characterized by cell structure damage and leukocyte infiltration, remains unknown. This study aimed to determine whether calpain, a protease inv...

Authors: Peng-Ran Du, Hong-Ting Lu, Xi-Xiang Lin, Li-Feng Wang, Yan-Xia Wang, Xiao-Ming Gu, Xiao-Zhi Bai, Ke Tao and Jing-Jun Zhou

Chinese expert consensus on clinical prevention and treatment of scar⁺

Following injury, Asian skin has a tendency toward hyperpigmentation and scar formation than Caucasians. A standardized algorithm tailored to Asian patients, especially Chinese patients, is in great demand. Tw...

Authors: Kaiyang Lv and Zhaofan Xia

Effect of non-steroidal anti-inflammatory drugs on post-surgical complications against the backdrop of the opioid crisis

The USA is currently going through an opioid crisis, associated with tremendous economic and societal impacts. In response to this crisis, healthcare professionals are looking for alternative pain management m...

Authors: Hannah Zhao-Fleming, Audrey Hand, Kelly Zhang, Robert Polak, Armand Northcut, Daron Jacob, Sharmila Dissanaike and Kendra P. Rumbaugh

Quantifying the impact of inhalational burns: a prospective study

Inhalational injury is a major cause of morbidity and mortality in burns patients. This study aims to analyse the clinical outcomes, complications and bacteriology of inhalational burn patients.

Authors: Si Jack Chong, Yee Onn Kok, Rosanna Xiang Ying Tay, Desai Suneel Ramesh, Kok Chai Tan and Bien Keem Tan