Figure 2
From: Role of CD8+ regulatory T cells in organ transplantation
Mechanisms underlying CD8+ Treg suppression. Mechanisms responsible for CD8+ Treg suppression include immunosuppressive cytokines and the killing of target T cells via the perforin/granzyme B and Fas L/Fas pathways as well as the downregulation of CD80/CD86 but the upregulation of immunoglobulin-like transcript 3/4 (ILT3/4) that, in turn, promotes CD8+ Treg expansion antigen presenting cell (APC).